IDENTIFICATION OF HOST FACTORS INVOLVED IN HUMAN CYTOMEGALOVIRUS REPLICATION, ASSEMBLY, AND EGRESS USING A TWO-STEP SMALL INTERFERING RNA SCREEN

Identification of Host Factors Involved in Human Cytomegalovirus Replication, Assembly, and Egress Using a Two-Step Small Interfering RNA Screen

ABSTRACT As obligate intracellular parasites, viruses are completely dependent on host factors for replication.Assembly and egress of complex virus particles, such as human cytomegalovirus (HCMV), are likely to require many host factors.Despite this, relatively few have been identified and characterized.This study describes a novel high-throughput,

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Inhibiting Type VI Secretion System Activity with a Biomimetic Peptide Designed To Target the Baseplate Wedge Complex

ABSTRACT Human health is threatened by bacterial infections that are increasingly resistant to multiple drugs.A recently emerged strategy consists of disarming pathogenic bacteria by targeting and blocking their virulence factors.The type VI secretion system (T6SS) is a widespread secretion nanomachine encoded and employed by pathogenic strains to

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